Which of the following correctly describes methadone in opioid use disorder treatment?

• A. Naloxone is used in OUD.
• B. Buprenorphine is a full agonist.
• C. Naltrexone is an antagonist.
• D. Methadone is a full opioid agonist used in OUD treatment, typically with daily supervised dosing.

Answer: (D)

Methadone works by fully activating mu-opioid receptors, providing a steady opioid effect that prevents withdrawal and cravings. Because it is long-acting, patients are typically given a daily supervised dose in treatment programs to support safety, adherence, and reduce relapse risk. This combination—full agonist activity with daily supervision—captures methadone’s role in opioid use disorder treatment. Other options describe different actions: naloxone reverses overdose as an antagonist; buprenorphine is a partial agonist; naltrexone is an antagonist that blocks opioid effects. Therefore, the description of methadone as a full opioid agonist used in OUD treatment, typically with daily supervised dosing, is the best fit.