Which medication used in the treatment of opioid addiction contains buprenorphine and naloxone?

• A. Suboxone
• B. Methadone
• C. Naltrexone
• D. Buprenorphine

Answer: (A)

This item tests knowledge of a medication that combines buprenorphine with naloxone to treat opioid use disorder and deter misuse. Suboxone contains buprenorphine, a partial opioid agonist that eases withdrawal and cravings without producing the full opioid effect. It also contains naloxone, an opioid antagonist included to discourage injection misuse. When the medication is taken as prescribed (sublingually), naloxone has minimal systemic effect, so it does not block the buprenorphine’s therapeutic action. If someone tries to inject it, the naloxone becomes active and can precipitate withdrawal, making misuse less appealing. Other options either provide buprenorphine without naloxone or are different types of medications (methadone is a full agonist; naltrexone is an antagonist; buprenorphine alone lacks naloxone), which is why Suboxone is the correct choice.