Which condition represents the progression from acute thiamine deficiency to persistent cognitive impairment?

• A. Wernicke-Korsakoff syndrome
• B. Wernicke encephalopathy
• C. Withdrawal
• D. Delirium tremens

Answer: (A)

Thiamine deficiency can start with an acute brain disorder called Wernicke encephalopathy. If this acute phase isn’t treated promptly, the brain damage can become chronic, leading to Korsakoff syndrome, which features persistent and often severe memory impairment and confabulation. When you describe both the acute phase and the lasting cognitive impairment together, you’re referring to Wernicke-Korsakoff syndrome. This name captures the progression from an acute thiamine deficiency to enduring cognitive deficits. Delirium tremens and general withdrawal are withdrawal-related states and don’t specifically describe this thiamine-related progression to long-term cognitive problems.