What are considerations for treatment of SUD in older adults?

• A. Polypharmacy and interactions
• B. Age-related pharmacokinetic changes
• C. Comorbidities
• D. All of the above

Answer: (D)

In older adults, treating substance use disorder requires accounting for aging-related changes and the broader medical context. Polypharmacy and interactions matter because many older individuals take multiple medications, and adding substances or MAT can interact with these drugs, increasing sedation, dizziness, or cardiovascular risk and complicating treatment effectiveness. Age-related pharmacokinetic changes also play a big role: slower metabolism and reduced renal clearance can lead to higher drug levels and longer effects, so doses may need adjustment and closer monitoring. Comorbidities are common and influence safety and choices in treatment; illnesses like cardiovascular disease, liver or kidney impairment, diabetes, or cognitive decline affect how medications work and what monitoring is needed, and they often require integrated care approaches. Taken together, these factors shape safer, more personalized treatment plans that aim to improve function and quality of life for older adults.